Please use this identifier to cite or link to this item:
Titre: Association des polymorphismes du gène méthylène-tétrahydrofolate réductase avec la leucémie myéloïde chronique
Auteur(s): Dorgham, Samia
Meriem Aberkane
Wefa Boughrara
Badra Antar Soltan
Nemra Mehalhal
Hadj Touhami
Mots-clés: MTHFR
Date de publication: 28-Apr-2015
Editeur: University of sciences and technology in Oran
Résumé: Methylene-tetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolism. Few studies were reported about its relationship with chronic myeloid leukemia (CML). We conducted a case-control study analyzing the prevalence of the polymorphisms MTHFR C677T and MTHFR A1298C in Algerians CML patients. Using TaqMan® allelic discrimination assay,we investigate MTHFR C677T and A1298C polymorphism distribution in 90 cases of CML and 100 healthy subjects. The frequencies of 677T alleles and genotypes 677TT and 677CT were significantly higher in cases than in control (P = 1E-6; OR= 6.77 [4.22-10.86]) and (P = 1E-6; OR= 10.38 [4.56-23.6]) respectively. Also, the frequencies of 1298C alleles and genotypes 1298CC and 1298AC were higher in cases (P = 9 E-6; OR= 2.65 [1.71-4.10]) and (P = 0.008; OR= 2.22 [1.21-4.06]) respectively. We report also the higher significance of the haplotype 677T/1298A and 677T/1298C in cases (P = 0.007; OR= 2.57 [1.26-5.24]) and (P = 5 E-6, OR= 6.91 [2.7646-17.2899]) respectively. Our results demonstrate that 677T and 1298C alleles are both associated with an increased risk of CML in Algeria.
Appears in Collections:Thèses doctorat

Files in This Item:
File Description SizeFormat 
article_dorgham.pdf614,58 kBAdobe PDFView/Open
These_dorgham_biblio.pdf2,73 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.